Release date: 18 December 2018
EDUCATIONAL OBJECTIVES
TARGET AUDIENCE
PROGRAMME OVERVIEW
In this activity, Highlights from ACR 2018 – Current and Future Perspectives in the Cytokine Signalling Blockade, a panel of international experts discuss current opinions in cytokine signalling.
Data from marketed JAK inhibitors continues to be positive, supporting the use of JAK inhibitors in the treatment of rheumatoid arthritis. This fast-paced arena creates an educational need to keep up-to-date with current research and maintain an awareness of promising new agents, current applications their influence on treatment paradigms.
This course, Highlights from ACR 2018 – Current and Future Perspectives in the Cytokine Signalling Blockade, outlines recent developments in cytokine signalling science and highlights the importance of these new data for clinical practice. The course is divided into three modules, each aligned to assessment questions and in accordance with the learning objectives.
INSTRUCTIONS FOR PARTICIPATION
DISCLOSURE OF CONFLICTS OF INTEREST
Please note that this course is currently awaiting accreditation.
Module | Presenter | Video | Questions |
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Introduction |
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Professor Iain B. McInnes
Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation, Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences. |
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New Phase 3 Data on New JAK Inhibitors |
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Professor Leonard Calabrese
Director & Professor of Medicine, Dr Leonard Calabrese is a Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and Vice Chair of the Department of Rheumatic and Immunologic Diseases. Dr Calabrese is the Director of the RJ Fasenmyer Center for Clinical Immunology at the Cleveland Clinic specialising in diseases of the immune system, in particular, immunodeficiency diseases including HIV. Dr Calabrese has extensively published on the safety of biologic therapies for autoimmune diseases including the epidemiology of opportunistic and viral infections including PML. Dr Calabrese is also the Co-director of the Center for Vasculitis Care and Research and holds a joint appointment in the Department of Infectious Diseases. Dr. Calabrese has lectured nationally and internationally on the subjects of clinical immunology, rheumatology and virology, and is the author of more than 400 published peer reviewed articles, book chapters and reviews. |
5 | |
Long term Safety Data in RA for Marketed JAK Inhibitors |
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Professor Iain B. McInnes
Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation, Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences. ![]()
Professor Leonard Calabrese
Director & Professor of Medicine, Dr Leonard Calabrese is a Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and Vice Chair of the Department of Rheumatic and Immunologic Diseases. Dr Calabrese is the Director of the RJ Fasenmyer Center for Clinical Immunology at the Cleveland Clinic specialising in diseases of the immune system, in particular, immunodeficiency diseases including HIV. Dr Calabrese has extensively published on the safety of biologic therapies for autoimmune diseases including the epidemiology of opportunistic and viral infections including PML. Dr Calabrese is also the Co-director of the Center for Vasculitis Care and Research and holds a joint appointment in the Department of Infectious Diseases. Dr. Calabrese has lectured nationally and internationally on the subjects of clinical immunology, rheumatology and virology, and is the author of more than 400 published peer reviewed articles, book chapters and reviews.
Professor Ian Bruce
Professor of Rheumatology, Director of the NIHR Manchester Biomedical Research Centre, Professor Ian Bruce is a Professor of Rheumatology and an NIHR Senior Investigator at the Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair.
He also serves as the Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility; Lead Clinician for The Kellgren Centre for Rheumatology, Central Manchester and Manchester Children's University Hospitals Trust; Director of the NIHR Manchester Biomedical Research Centre; and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. Professor Bruce studied medicine at Queen's University Belfast, and was the Geoff Carr Lupus Fellow at the University of Toronto.
Professor Bruce is a Fellow of the Royal College of Physicians of London, a member of the British Society for Rheumatology and the American College of Rheumatology, and is the Chair of the Systemic Lupus International Collaborating Clinics.
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01:52 | 4 |
Novel Applications on JAK Inhibitors |
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Professor Iain B. McInnes
Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation, Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.
Professor Ian Bruce
Professor of Rheumatology, Director of the NIHR Manchester Biomedical Research Centre, Professor Ian Bruce is a Professor of Rheumatology and an NIHR Senior Investigator at the Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair.
He also serves as the Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility; Lead Clinician for The Kellgren Centre for Rheumatology, Central Manchester and Manchester Children's University Hospitals Trust; Director of the NIHR Manchester Biomedical Research Centre; and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. Professor Bruce studied medicine at Queen's University Belfast, and was the Geoff Carr Lupus Fellow at the University of Toronto.
Professor Bruce is a Fellow of the Royal College of Physicians of London, a member of the British Society for Rheumatology and the American College of Rheumatology, and is the Chair of the Systemic Lupus International Collaborating Clinics.
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3 | |
Close |
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Professor Iain B. McInnes
Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation, Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences. |
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Evaluation | 17 |
Date of preparation: