Cytokine Signalling Forum

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Highlights from ACR 2018: Current and Future Perspectives in the Cytokine Signalling Blockade


Developed by CESAS Medical, under the auspices of the University of Glasgow This activity is supported by unrestricted educational grants from Pfizer Italia S.R.L. and Eli Lilly

Release date: 18 December 2018
Estimated time to complete activity: 1 1/2 hours
Compatible with all modern internet browsers and mobile devices

EDUCATIONAL OBJECTIVES
After completing this activity, the learner will be able to:
  • Discuss the latest phase 3 clinical data for new JAK inhibitors in rheumatoid arthritis
  • Explain the latest long-term safety data on marketed JAK inhibitors in rheumatoid arthritis
  • Appreciate the new indications currently being investigated for JAK inhibitors

TARGET AUDIENCE
This activity is designed for rheumatologists and other healthcare professionals involved in treating patients with rheumatic disease.

PROGRAMME OVERVIEW
ACR 2018 presented new scientific and clinical information on cytokine signalling science that will shape the rheumatology treatment landscape. Data presented included those relating to marketed cytokine signalling agents, newer agents and new indications for established treatments.

In this activity, Highlights from ACR 2018 – Current and Future Perspectives in the Cytokine Signalling Blockade, a panel of international experts discuss current opinions in cytokine signalling.

Data from marketed JAK inhibitors continues to be positive, supporting the use of JAK inhibitors in the treatment of rheumatoid arthritis. This fast-paced arena creates an educational need to keep up-to-date with current research and maintain an awareness of promising new agents, current applications their influence on treatment paradigms.

This course, Highlights from ACR 2018 – Current and Future Perspectives in the Cytokine Signalling Blockade, outlines recent developments in cytokine signalling science and highlights the importance of these new data for clinical practice. The course is divided into three modules, each aligned to assessment questions and in accordance with the learning objectives.

INSTRUCTIONS FOR PARTICIPATION
Participants must 1) read the activity information; 2) study the educational activity; 3) successfully complete the post-module assessments with a score of 80% or better; 4) and complete the evaluation form. Upon completion of the full activity, your certificate will be made available to download and print.

DISCLOSURE OF CONFLICTS OF INTEREST
CESAS Medical requires faculty, presenters, planners, managers, writers, and any other individuals who are in a position to influence the content of this activity to disclose any real and/or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly reviewed and resolved according to CESAS Medical policy.

Please note that this course is currently awaiting accreditation.

Module Présentateur Vidéo Questions
Introduction
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
New Phase 3 Data on New JAK Inhibitors
Professor Leonard Calabrese image
Professor Leonard Calabrese

Director & Professor of Medicine,
RJ Fasenmyer Center for Clinical Immunology, Cleveland Clinic Foundation, Ohio, USA

Dr Leonard Calabrese is a Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and Vice Chair of the Department of Rheumatic and Immunologic Diseases. Dr Calabrese is the Director of the RJ Fasenmyer Center for Clinical Immunology at the Cleveland Clinic specialising in diseases of the immune system, in particular, immunodeficiency diseases including HIV. Dr Calabrese has extensively published on the safety of biologic therapies for autoimmune diseases including the epidemiology of opportunistic and viral infections including PML. Dr Calabrese is also the Co-director of the Center for Vasculitis Care and Research and holds a joint appointment in the Department of Infectious Diseases.

Dr. Calabrese has lectured nationally and internationally on the subjects of clinical immunology, rheumatology and virology, and is the author of more than 400 published peer reviewed articles, book chapters and reviews.

Prof. Leonard Calabrese (Bio)
5
Long term Safety Data in RA for Marketed JAK Inhibitors
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
Professor Leonard Calabrese image
Professor Leonard Calabrese

Director & Professor of Medicine,
RJ Fasenmyer Center for Clinical Immunology, Cleveland Clinic Foundation, Ohio, USA

Dr Leonard Calabrese is a Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and Vice Chair of the Department of Rheumatic and Immunologic Diseases. Dr Calabrese is the Director of the RJ Fasenmyer Center for Clinical Immunology at the Cleveland Clinic specialising in diseases of the immune system, in particular, immunodeficiency diseases including HIV. Dr Calabrese has extensively published on the safety of biologic therapies for autoimmune diseases including the epidemiology of opportunistic and viral infections including PML. Dr Calabrese is also the Co-director of the Center for Vasculitis Care and Research and holds a joint appointment in the Department of Infectious Diseases.

Dr. Calabrese has lectured nationally and internationally on the subjects of clinical immunology, rheumatology and virology, and is the author of more than 400 published peer reviewed articles, book chapters and reviews.

Prof. Leonard Calabrese (Bio)
Professor Ian Bruce image
Professor Ian Bruce

Professor of Rheumatology, Director of the NIHR Manchester Biomedical Research Centre,
University of Manchester, UK

Professor Ian Bruce is a Professor of Rheumatology and an NIHR Senior Investigator at the Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair. He also serves as the Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility; Lead Clinician for The Kellgren Centre for Rheumatology, Central Manchester and Manchester Children's University Hospitals Trust; Director of the NIHR Manchester Biomedical Research Centre; and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. Professor Bruce studied medicine at Queen's University Belfast, and was the Geoff Carr Lupus Fellow at the University of Toronto. Professor Bruce is a Fellow of the Royal College of Physicians of London, a member of the British Society for Rheumatology and the American College of Rheumatology, and is the Chair of the Systemic Lupus International Collaborating Clinics.
Prof. Ian Bruce (Bio)
01:52 4
Novel Applications on JAK Inhibitors
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
Professor Ian Bruce image
Professor Ian Bruce

Professor of Rheumatology, Director of the NIHR Manchester Biomedical Research Centre,
University of Manchester, UK

Professor Ian Bruce is a Professor of Rheumatology and an NIHR Senior Investigator at the Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair. He also serves as the Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility; Lead Clinician for The Kellgren Centre for Rheumatology, Central Manchester and Manchester Children's University Hospitals Trust; Director of the NIHR Manchester Biomedical Research Centre; and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. Professor Bruce studied medicine at Queen's University Belfast, and was the Geoff Carr Lupus Fellow at the University of Toronto. Professor Bruce is a Fellow of the Royal College of Physicians of London, a member of the British Society for Rheumatology and the American College of Rheumatology, and is the Chair of the Systemic Lupus International Collaborating Clinics.
Prof. Ian Bruce (Bio)
3
Close
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
Evaluation 17

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