Cytokine Signalling Forum
CME Courses
Highlights from ACR 2018: Current and Future Perspectives in the Cytokine Signalling Blockade
Developed by CESAS Medical, under the auspices of the University of Glasgow. This activity is supported by unrestricted educational grants from Pfizer Italia S.R.L. and Lilly
Expiration date:15 July 2021
Estimated time to complete activity:1.5 hours
Compatible with all modern internet browsers and mobile devices
EDUCATIONAL OBJECTIVES
After completing this activity, the learner will be able to:
- Discuss the latest phase 3 clinical data for new JAK inhibitors in rheumatoid arthritis
- Explain the latest long-term safety data on marketed JAK inhibitors in rheumatoid arthritis
- Appreciate the new indications currently being investigated for JAK inhibitors
TARGET AUDIENCE
This activity is designed for rheumatologists and other healthcare professionals involved in treating patients with rheumatic disease.
PROGRAMME OVERVIEW
In this activity, Highlights from ACR 2018 – Current and Future Perspectives in the Cytokine Signalling Blockade, a panel of international experts discuss current opinions in cytokine signalling. Data from marketed JAK inhibitors continues to be positive, supporting the use of JAK inhibitors in the treatment of rheumatoid arthritis. This course, outlines recent developments in cytokine signalling science and highlights the importance of these new data for clinical practice. The course is divided into three modules, each aligned to assessment questions and in accordance with the learning objectives.
INSTRUCTIONS FOR PARTICIPATION
Participants must 1) read the activity information; 2) study the educational activity; 3) successfully complete post-module assessments with a score of ≥80%; 4) and complete the evaluation form. Upon completion of the full activity, your certificate will be made available to download and print.
DISCLOSURE OF CONFLICTS OF INTEREST
CESAS Medical requires faculty, presenters, planners, managers, writers, and any other individuals who are in a position to influence the content of this activity to disclose any real and/or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly reviewed and resolved according to CESAS Medical policy.
ACCREDITATION STATEMENT
The e-learning activity, Highlights from ACR 2018 – Current and Future Perspectives in the Cytokine Signalling Blockade, organised by CESAS Medical, under the auspices of the University of Glasgow, is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The e-learning activity, Highlights from ACR 2018 – Current and Future Perspectives in the Cytokine Signalling Blockade, organised by CESAS Medical, under the auspices of the University of Glasgow, is awarded 1 European CME credits (ECMECs).
Each medical specialist should claim only those credits that he/she actually spent in the educational activity. The EACCME is an institution of the European Union of Medical Specialists (UEMS). Only those e-learning materials that are displayed on the UEMS-EACCME website have formally been accredited. Through an agreement between the European Union of Medical Specialists (UEMS) and the American Medical Association (AMA), physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits. Information on the process to convert EACCME credit to AMA credit can be found at www.ama-assn.org/education/earn-credit-participation-international-activities.
| Module | Presenter | Video | Questions |
|---|---|---|---|
| Introduction |
Professor Iain B. McInnes
Vice Principal and Head of College of Medical, Veterinary and Life Sciences (MVLS) President of European Alliance of Associations for Rheumatology (EULAR), Professor Iain McInnes is the Vice Principal and Head of College of MVLS in the University of Glasgow, UK. He is also the current President of the EULAR, the leading trans-national society for rheumatology across Europe. Professor McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. He has extensive experience in leading multicentre programmes, nationally and internationally. Professor McInnes is also Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Programme; Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery programme (PROMISERA); and Chief Investigator of numerous global phase II and III clinical trials of novel immune therapies His major interest is in the biology of inflammatory synovitis in rheumatoid arthritis, psoriatic arthritis and septic arthritis. He operates on a translational science programme in which state of the art cellular and molecular biology techniques are applied to elucidate the mechanisms underlying the perpetuation of a range of chronic diseases seeking to build precision medicine approaches and new therapeutics thereafter. He received the Sir James Black Prize Medal, a prestigious award in medicine in 2016 by the Royal Society of Edinburgh for his outstanding contribution to the field of immunology. In 2019, Professor McInnes was awarded a CBE for his services to Medicine. |
02:13 | |
| New Phase 3 Data on New JAK Inhibitors |
Professor Leonard Calabrese
Director & Professor of Medicine, Leonard Calabrese is a Professor of Medicine, Vice Chair of the Cleveland Clinic’s Department of Rheumatic and Immunologic Diseases and the Co-director of the Centre for Vasculitis Care and Research. He also serves as Director of the RJ Fasenmyer Centre for Clinical Immunology at the Cleveland Clinic. He also holds appointments in the Department of Infectious Diseases and the Wellness Institute. He is a graduate of the Kansas City University of Medicine and Biosciences. Completed his internal medicine training at the Cleveland Clinic Foundation in Ohio, followed by a fellowship in rheumatic and immunologic disease. Professor Calabrese has received numerous awards, including honorary Doctorates of Humane Letters from the Kansas City University of Medicine and Biosciences and Alma College and the Leonard Tow Humanitarianism in Medicine award from the Arnold P Goldman MD Foundation. He has particular interest in vascular inflammatory disease of the central nervous system, primary and secondary immunodeficiency states and the intersection of infections and autoimmunity. Over the course of his academic research career, Professor Calabrese has authored over 400 publications including book chapters and peer-reviewed journal articles. |
30:27 | 5 |
| Long term Safety Data in RA for Marketed JAK Inhibitors |
Professor Iain B. McInnes
Vice Principal and Head of College of Medical, Veterinary and Life Sciences (MVLS) President of European Alliance of Associations for Rheumatology (EULAR), Professor Iain McInnes is the Vice Principal and Head of College of MVLS in the University of Glasgow, UK. He is also the current President of the EULAR, the leading trans-national society for rheumatology across Europe. Professor McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. He has extensive experience in leading multicentre programmes, nationally and internationally. Professor McInnes is also Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Programme; Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery programme (PROMISERA); and Chief Investigator of numerous global phase II and III clinical trials of novel immune therapies His major interest is in the biology of inflammatory synovitis in rheumatoid arthritis, psoriatic arthritis and septic arthritis. He operates on a translational science programme in which state of the art cellular and molecular biology techniques are applied to elucidate the mechanisms underlying the perpetuation of a range of chronic diseases seeking to build precision medicine approaches and new therapeutics thereafter. He received the Sir James Black Prize Medal, a prestigious award in medicine in 2016 by the Royal Society of Edinburgh for his outstanding contribution to the field of immunology. In 2019, Professor McInnes was awarded a CBE for his services to Medicine.
Professor Leonard Calabrese
Director & Professor of Medicine, Leonard Calabrese is a Professor of Medicine, Vice Chair of the Cleveland Clinic’s Department of Rheumatic and Immunologic Diseases and the Co-director of the Centre for Vasculitis Care and Research. He also serves as Director of the RJ Fasenmyer Centre for Clinical Immunology at the Cleveland Clinic. He also holds appointments in the Department of Infectious Diseases and the Wellness Institute. He is a graduate of the Kansas City University of Medicine and Biosciences. Completed his internal medicine training at the Cleveland Clinic Foundation in Ohio, followed by a fellowship in rheumatic and immunologic disease. Professor Calabrese has received numerous awards, including honorary Doctorates of Humane Letters from the Kansas City University of Medicine and Biosciences and Alma College and the Leonard Tow Humanitarianism in Medicine award from the Arnold P Goldman MD Foundation. He has particular interest in vascular inflammatory disease of the central nervous system, primary and secondary immunodeficiency states and the intersection of infections and autoimmunity. Over the course of his academic research career, Professor Calabrese has authored over 400 publications including book chapters and peer-reviewed journal articles.
Professor Ian Bruce
Professor of Rheumatology, Director of the NIHR Manchester Biomedical Research Centre, Professor Ian Bruce is a Professor of Rheumatology and an NIHR Senior Investigator at the Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair.
He also serves as the Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility; Lead Clinician for The Kellgren Centre for Rheumatology, Central Manchester and Manchester Children's University Hospitals Trust; Director of the NIHR Manchester Biomedical Research Centre; and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. Professor Bruce studied medicine at Queen's University Belfast, and was the Geoff Carr Lupus Fellow at the University of Toronto.
Professor Bruce is a Fellow of the Royal College of Physicians of London, a member of the British Society for Rheumatology and the American College of Rheumatology, and is the Chair of the Systemic Lupus International Collaborating Clinics.
|
14:28 | 4 |
| Novel Applications on JAK Inhibitors |
Professor Iain B. McInnes
Vice Principal and Head of College of Medical, Veterinary and Life Sciences (MVLS) President of European Alliance of Associations for Rheumatology (EULAR), Professor Iain McInnes is the Vice Principal and Head of College of MVLS in the University of Glasgow, UK. He is also the current President of the EULAR, the leading trans-national society for rheumatology across Europe. Professor McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. He has extensive experience in leading multicentre programmes, nationally and internationally. Professor McInnes is also Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Programme; Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery programme (PROMISERA); and Chief Investigator of numerous global phase II and III clinical trials of novel immune therapies His major interest is in the biology of inflammatory synovitis in rheumatoid arthritis, psoriatic arthritis and septic arthritis. He operates on a translational science programme in which state of the art cellular and molecular biology techniques are applied to elucidate the mechanisms underlying the perpetuation of a range of chronic diseases seeking to build precision medicine approaches and new therapeutics thereafter. He received the Sir James Black Prize Medal, a prestigious award in medicine in 2016 by the Royal Society of Edinburgh for his outstanding contribution to the field of immunology. In 2019, Professor McInnes was awarded a CBE for his services to Medicine.
Professor Ian Bruce
Professor of Rheumatology, Director of the NIHR Manchester Biomedical Research Centre, Professor Ian Bruce is a Professor of Rheumatology and an NIHR Senior Investigator at the Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair.
He also serves as the Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility; Lead Clinician for The Kellgren Centre for Rheumatology, Central Manchester and Manchester Children's University Hospitals Trust; Director of the NIHR Manchester Biomedical Research Centre; and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. Professor Bruce studied medicine at Queen's University Belfast, and was the Geoff Carr Lupus Fellow at the University of Toronto.
Professor Bruce is a Fellow of the Royal College of Physicians of London, a member of the British Society for Rheumatology and the American College of Rheumatology, and is the Chair of the Systemic Lupus International Collaborating Clinics.
|
18:08 | 3 |
| Close |
Professor Iain B. McInnes
Vice Principal and Head of College of Medical, Veterinary and Life Sciences (MVLS) President of European Alliance of Associations for Rheumatology (EULAR), Professor Iain McInnes is the Vice Principal and Head of College of MVLS in the University of Glasgow, UK. He is also the current President of the EULAR, the leading trans-national society for rheumatology across Europe. Professor McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA. He has extensive experience in leading multicentre programmes, nationally and internationally. Professor McInnes is also Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Programme; Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery programme (PROMISERA); and Chief Investigator of numerous global phase II and III clinical trials of novel immune therapies His major interest is in the biology of inflammatory synovitis in rheumatoid arthritis, psoriatic arthritis and septic arthritis. He operates on a translational science programme in which state of the art cellular and molecular biology techniques are applied to elucidate the mechanisms underlying the perpetuation of a range of chronic diseases seeking to build precision medicine approaches and new therapeutics thereafter. He received the Sir James Black Prize Medal, a prestigious award in medicine in 2016 by the Royal Society of Edinburgh for his outstanding contribution to the field of immunology. In 2019, Professor McInnes was awarded a CBE for his services to Medicine. |
00:55 | |
| Evaluation | 17 |
Date of preparation: 18 December 2018